Chemistry & Biochemistry: Recent submissions

  • Siddiqui, M. Quadir; Badmalia, Maulik D.; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/ijms22052647, 2021)
    Members of the human Zyxin family are LIM domain-containing proteins that perform critical cellular functions and are indispensable for cellular integrity. Despite their importance, not much is known about their structure, ...
  • Meier-Stephenson, Vanessa; Badmalia, Maulik D.; Mrozowich, Tyler; Lau, Keith C. K.; Schultz, Sarah K.; Gemmill, Darren L.; Osiowy, Carla; van Marle, Guido; Coffin, Carla S.; Patel, Trushar R. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryPublic Health Agency of CanadaUniversity of Albertahttps://doi.org/10.1016/j.jbc.2021.100589, 2021)
    Approximately 250 million people worldwide are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing cirrhosis and hepatocellular carcinoma. The HBV genome persists as covalently ...
  • Rutbeek, Nicole R.; Rezasoltani, Hanieh; Patel, Trushar R.; Khajehpour, Mazdak; Prehna, Gerd (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of ManitobaUniversity of Lethbridge, 2021)
    Streptococcus pyogenes, or Group A Streptococcus, is a Gram-positive bacterium that can be both a human commensal and a pathogen. Central to this dichotomy are temperate bacteriophages that incorporate into the bacterial ...
  • Mullen, Patrick; Abbott, Jamie A.; Wellman, Theresa; Aktar, Mahafuza; Fjeld, Christian; Demeler, Borries; Ebert, Alicia M.; Francklyn, Christopher S. (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VermontUniversity of Lethbridgehttps://doi.org/10.1111/febs.15449, 2021)
    Charcot-Marie-Tooth disease (CMT) encompasses a set of genetically and clinically heterogeneous neuropathies characterized by length dependent dysfunction of the peripheral nervous system. Mutations in over 80 diverse genes ...
  • Koebke, Karl J.; Kühl, Toni; Lojou, Elisabeth; Demeler, Borries; Schoepp-Cothenet, Barbara; Iranzo, Olga; Pecoraro, Vincent L.; Ivancich, Anabella (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MichiganAix-Marseille UniversityUniversity of Lethbridgehttps://doi.org/10.1002/anie.202012673, 2021)
    De Novo metalloprotein design assesses the relationship between metal active site architecture and catalytic reactivity. Herein, we use an α-helical scaffold to control the iron coordination geometry when a heme cofactor ...
  • Tersteeg, Scott; Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (Canadian Science PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of AlbertaUniversity of Calgaryhttps://doi.org/10.1139/bcb-2022-0118, 2022)
    Inorganic pyrophosphatase (iPPase) is an enzyme that cleaves pyrophosphate into two phosphate molecules. This enzyme is an essential component of in vitro transcription (IVT) reactions for RNA preparation as it prevents ...
  • Bykowski, Janelle; Turnbull, Douglas; Hahn, Nolan; Boeré, René T.; Wetmore, Stacey D.; Gerken, Michael (ACS PublicationsArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1021/acs.inorgchem.1c02380, 2021)
    The Lewis acid–base adducts MoF5(NC5H5)n and MoOF4(NC5H5)n (n = 1, 2) were synthesized from the reactions of MoF5 and MoOF4 with C5H5N and structurally characterized by X-ray crystallography. Whereas the crystal structures ...
  • Soares, Barbara S.; Rocha, Surza Lucia G.; Bastos, Viviane A.; Lima, Diogo B.; Carvalho, Paulo C.; Gozzo, Fabio C.; Demeler, Borries; Williams, Tayler L.; Arnold, Janelle; Henrickson, Amy; Jorgensen, Thomas J. D.; Souza, Tatiana A. C. B.; Perales, Jonas; Valente, Richard H.; Lomonte, Bruno; Gomes-Neto, Francisco; Neves-Ferreira, Ana Gisele C. (Frontiers Research FoundationArts and ScienceDepartment of Chemistry and BiochemistryOswaldo Cruz InstituteLeibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)Carlos Chagas InstituteUniversity of CampinasUniversity of Texas Health Science Center at San AntonioUniversity of LethbridgeUniversity of MontanaPrinceton UniversityUniversity of Southern DenmarkUniversity of Costa Ricahttps://doi.org/10.3389/fmolb.2021.787368, 2022)
    DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account ...
  • D'Souza, Michael H.; Mrozowich, Tyler; Badmalia, Maulik D.; Geeraert, Mitchell; Frederickson, Angela; Henrickson, Amy; Demeler, Borries; Wolfinger, Michael T.; Patel, Trushar R. (Oxford University PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryUniversity of MontanaUniversity of ViennaUniversity of Albertahttps://doi.org/10.1093/nar/gkac414, 2022)
    Human Long Intergenic Noncoding RNA-p21 (LincRNA-p21) is a regulatory noncoding RNA that plays an important role in promoting apoptosis. LincRNA-p21 is also critical in down-regulating many p53 target genes through its ...
  • Evans, Chiara M.; Phillips, Margaret; Malone, Kiera L.; Tonelli, Marco; Cornilescu, Gabriel; Cornilescu, Claudia; Holton, Simon J.; Gorjánácz, Mátyás; Wang, Liping; Carlson, Samuel; Gay, Jamie C.; Nix, Jay C.; Demeler, Borries; Markley, John L.; Glass, Karen C. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryAlbany College of Pharmacy and Health SciencesUniversity of VermontUniversity of Wisconsin-MadisonBayer AGUniversity of Texas Health San AntonioMolecular Biology ConsortiumUniversity of Lethbridgehttps://doi.org/10.3390/ijms22179128, 2021)
    The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four -helices. ATAD2 functions as a coactivator of the androgen and estrogen receptors as ...
  • Guimaraes, Ivelise D. L.; Marszaukowski, Flávia; Rutka, Priscila B.; Borge, Luis F.; Ribeiro, Renan A. P.; Ricardo de Lazaro, Sergio; Castellen, Patrícia; Sagoe-Wagner, Araba; Golsteyn, Roy M.; Boeré, René T.; Wohnrath, Karen (ElsevierArts and ScienceDepartment of Biological SciencesDepartment of Chemistry and BiochemistryUniversidade Estadual de Ponta GrossaUniversidade do Estado de Minas GeraisInstituto Federal Catarinense, Rua das RosasUniversity of Lethbridgehttps://doi.org/10.1016/j.poly.2022.115980, 2022)
    Ruthenium-based anticancer agents have created a center of attention in the field of inorganic medicinal chemistry. The first fully characterized cationic ruthenium(II)-arene complexes [Ru(η6-p-cymene) (PAr3)LNCl]+ with ...
  • Ibrahim, Mukaila A.; Boeré, René T. (Royal Society of ChemistryArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1039/D2NJ00169A, 2022)
    New structure determinations of CuSO4, CuSO4 H2O, CuSO4 3H2O and CuSO4 5H2O are reported from X-ray diffraction experiments at 100 (1) K. Combined density functional theory (ORCA) and non-spherical atomic scattering ...
  • Marszaukowski, Flávia; Boeré, René T.; Wohnrath, Karen (ACS PublicationsArts and ScienceDepartment of Chemistry and BiochemistryUniversidade Estadual de Ponta GrossaUniversity of Lethbridgehttps://doi.org/10.1021/acs.cgd.2c00020, 2022)
    Synthesis and molecular and supramolecular structures of a series of triarylphosphines P(Ph)3–n{4-RO-3,5-(tBu)2-C6H2}n (n = 1, 3; R = SiMe3, H) are reported. Chemical oxidation products E=P(Ph)3–n{4-RO-3,5-(tBu)2-C6H2}n ...
  • Ramachandran, Mridhul R. K.; Schnakenburg, Gregor; Majumdar, Moumita; Kelemen, Zsolt; Gal, Dalma; Nyulaszi, Laszlo; Boeré, René T.; Streubel, Rainer K. (ACS PublicationsArts and ScienceDepartment of Chemistry and BiochemistryRheinische Friedrich-Wilhelms-Universitat BonnIndian Institute of Science Education and ResearchBudapest University of Technology and EconomicsUniversity of Lethbridgehttps://doi.org/10.1021/acs.inorgchem.1c03620, 2022)
    Anionic 1,4-dihydro-1,4-diphosphinines were synthesized from tricyclic 1,4-diphosphinines and isolated as blue powdery salts M[2a–2c]. Reaction of solutions of these monoanions with iodomethane led to P-methylated compounds ...
  • Drescher, Sam L.; Forfar, Christopher P.; Boeré, René T.; Hayes, Paul G. (Arts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1107/S2056989021009221, 2021)
    The compound bis­{μ3-2,5-bis­[N-(4-iso­propyl­phen­yl)-P,P-di­phenyl­phospho­r­im­i­do­yl]pyrrol-1-ido-κ3N:N′:N′′}tris­ilver(I) tri­fluoro­methane­sulfonate deuterated benzene penta­solvate, [Ag3(C46H44N3P2)2](CF3O3S)·5C6D6, ...
  • Marasco, Olivia N. J. M.; Roussel, Marc R.; Thakor, Nehal (ElsevierArts and ScienceDepartment of Biological SciencesDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of Calgaryhttps://doi.org/10.1016/j.mbs.2021.108762, 2022)
    ATF4 is a key transcription factor that activates transcription of genes needed to respond to cellular stress. Although the mRNA encoding ATF4 is present at constant levels in the cell during the initial response, translation ...
  • Villarreal, Oscar D.; Chen, Liao Y.; Whetten, Robert L.; Demeler, Borries (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas at San AntonioUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.5b09864, 2015)
    Nanometer-sized gold particles (AuNPs) are of peculiar interest because their behaviors in an aqueous solution are sensitive to changes in environmental factors including the size and shape of the solute ions. In order to ...
  • Ballandras-Colas, Allison; Brown, Monica; Cook, Nicola J.; Dewdney, Tamaria G.; Demeler, Borries; Cherepanov, Peter; Lyumkis, Dmitry; Engelman, Alan N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryHarvard Medical SchoolThe Salk Institute for Biological StudiesThe Francis Crick InstituteUniversity of Texas Health Science Center at San AntonioImperial College LondonUniversity of Lethbridgehttps://doi.org/10.1038/nature16955, 2016)
    Retroviral integrase catalyses the integration of viral DNA into host target DNA, which is an essential step in the life cycle of all retroviruses1. Previous structural characterization of integrase–viral DNA complexes, ...
  • Alvarez, Marcos M.; Chen, Jenny; Plascencia-Villa, German; Black, David M.; Griffiths, Wendell P.; Garzon, Ignacio L.; Jose-Yacaman, Miguel; Demeler, Borrie; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasThermoFisher ScientificUniversidad Nacional Autonoma de MexicoUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.6b04525, 2016)
    Experimental and theoretical evidence reveals the resilience and stability of the larger aqueous gold clusters protected with p-mercaptobenzoic acid ligands (pMBA) of composition Aun(pMBA)p or (n, p). The Au144(pMBA)60, ...
  • Rubio-Marrero, Eva N.; Vincelli, Gabriele; Jeffries, Cy M.; Shaikh, Tanvir R.; Pakos, Irene S.; Ranaivoson, Fanomezana M.; von Daake, Sventja; Demeler, Borries; De Jaco, Antonella; Perkins, Guy; Ellisman, Mark H.; Trewhella, Jill; Comoletti, Davide (ASBMB PublicationsArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityUniversity of SydneyMasaryk UniversityUniversity of Texas Health Science Center at San AntonioSapienza University of RomeUniversity of California San DiegoUniversity of UtahUniversity of Lethbridgehttps://doi.org/10.1074/jbc.M115.705681, 2015)
    Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including ...