Thakor, Nehalkumar

 

Recent Submissions

  • Probabilistic models of uORF-mediated ATF4 translation control 
    Marasco, Olivia N. J. M.; Roussel, Marc R.; Thakor, Nehal (ElsevierArts and ScienceDepartment of Biological SciencesDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of Calgaryhttps://doi.org/10.1016/j.mbs.2021.108762, 2022)
    ATF4 is a key transcription factor that activates transcription of genes needed to respond to cellular stress. Although the mRNA encoding ATF4 is present at constant levels in the cell during the initial response, translation ...
  • Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal Kinase (JNK). 
    Bressler, Kamiko R.; Ross, Joseph A.; Ilnytskyy, Slava; Vanden Dungen, Keiran; Taylor, Katrina; Patel, Kush; Zovoilis, Athanasios; Kovalchuk, Igor; Thakor, Nehal (SpringerArts and ScienceDepartment of Chemistry and BiochemistryDepartment of Biological SciencesDepartment of NeuroscienceUniversity of LethbridgeUniversity of Calgaryhttps://doi.org/10.1007/s12192-020-01174-1, 2021)
    During the integrated stress response (ISR), global translation initiation is attenuated; however, noncanonical mechanisms allow for the continued translation of specific transcripts. Eukaryotic initiation factor 5B (eIF5B) ...
  • Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs) 
    Ross, Joseph A.; Ahn, Bo Young; King, Jennifer; Bressler, Kamiko R.; Senger, Donna L.; Thakor, Nehal (Canadian Science PublishingArts and ScienceDepartment of Chemistry and BiochemistryDepartment of NeuroscienceUniversity of LethbridgeUniversity of Calgaryhttps://doi.org/10.1139/bcb-2019-0329, 2019)
    Glioblastoma multiforme (GBM) is among the deadliest cancers, owing in part to complex inter- and intra-tumor heterogeneity and the presence of a population of stem-like cells called brain tumor stem cells (BTSCs/BTICs). ...
  • Cellular roles of the human Obg-like ATPase 1 (hOLA1) and its YchF homologs 
    Balasingam, Nirujah; Brandon, Harland E.; Ross, Joseph A.; Wieden, Hans-Joachim; Thakor, Nehal (Canadian Science PublishingArts and ScienceAlberta RNA Research and Training (ARRTI)Department of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1139/bcb-2018-0353, 2020)
    P-loop NTPases comprise one of the major superfamilies of nucleotide binding proteins, which mediate a variety of cellular processes, such as mRNA translation, signal transduction, cell motility, and growth regulation. In ...
  • Applications and limitations of regulatory RNA elements in synthetic biology and biotechnology 
    Nshogozabahizi, J. C.; Aubrey, K. L.; Ross, J. A.; Thakor, Nehal (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1111/jam.14270, 2019)
    Synthetic biology requires the design and implementation of novel enzymes, genetic circuits or even entire cells, which can be controlled by the user. RNA‐based regulatory elements have many important functional properties ...