Demeler, Borries

 

Recent Submissions

  • Mullen, Patrick; Abbott, Jamie A.; Wellman, Theresa; Aktar, Mahafuza; Fjeld, Christian; Demeler, Borries; Ebert, Alicia M.; Francklyn, Christopher S. (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VermontUniversity of Lethbridgehttps://doi.org/10.1111/febs.15449, 2021)
    Charcot-Marie-Tooth disease (CMT) encompasses a set of genetically and clinically heterogeneous neuropathies characterized by length dependent dysfunction of the peripheral nervous system. Mutations in over 80 diverse genes ...
  • Koebke, Karl J.; Kühl, Toni; Lojou, Elisabeth; Demeler, Borries; Schoepp-Cothenet, Barbara; Iranzo, Olga; Pecoraro, Vincent L.; Ivancich, Anabella (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MichiganAix-Marseille UniversityUniversity of Lethbridgehttps://doi.org/10.1002/anie.202012673, 2021)
    De Novo metalloprotein design assesses the relationship between metal active site architecture and catalytic reactivity. Herein, we use an α-helical scaffold to control the iron coordination geometry when a heme cofactor ...
  • Tersteeg, Scott; Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (Canadian Science PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of AlbertaUniversity of Calgaryhttps://doi.org/10.1139/bcb-2022-0118, 2022)
    Inorganic pyrophosphatase (iPPase) is an enzyme that cleaves pyrophosphate into two phosphate molecules. This enzyme is an essential component of in vitro transcription (IVT) reactions for RNA preparation as it prevents ...
  • Soares, Barbara S.; Rocha, Surza Lucia G.; Bastos, Viviane A.; Lima, Diogo B.; Carvalho, Paulo C.; Gozzo, Fabio C.; Demeler, Borries; Williams, Tayler L.; Arnold, Janelle; Henrickson, Amy; Jorgensen, Thomas J. D.; Souza, Tatiana A. C. B.; Perales, Jonas; Valente, Richard H.; Lomonte, Bruno; Gomes-Neto, Francisco; Neves-Ferreira, Ana Gisele C. (Frontiers Research FoundationArts and ScienceDepartment of Chemistry and BiochemistryOswaldo Cruz InstituteLeibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)Carlos Chagas InstituteUniversity of CampinasUniversity of Texas Health Science Center at San AntonioUniversity of LethbridgeUniversity of MontanaPrinceton UniversityUniversity of Southern DenmarkUniversity of Costa Ricahttps://doi.org/10.3389/fmolb.2021.787368, 2022)
    DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account ...
  • D'Souza, Michael H.; Mrozowich, Tyler; Badmalia, Maulik D.; Geeraert, Mitchell; Frederickson, Angela; Henrickson, Amy; Demeler, Borries; Wolfinger, Michael T.; Patel, Trushar R. (Oxford University PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryUniversity of MontanaUniversity of ViennaUniversity of Albertahttps://doi.org/10.1093/nar/gkac414, 2022)
    Human Long Intergenic Noncoding RNA-p21 (LincRNA-p21) is a regulatory noncoding RNA that plays an important role in promoting apoptosis. LincRNA-p21 is also critical in down-regulating many p53 target genes through its ...
  • Evans, Chiara M.; Phillips, Margaret; Malone, Kiera L.; Tonelli, Marco; Cornilescu, Gabriel; Cornilescu, Claudia; Holton, Simon J.; Gorjánácz, Mátyás; Wang, Liping; Carlson, Samuel; Gay, Jamie C.; Nix, Jay C.; Demeler, Borries; Markley, John L.; Glass, Karen C. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryAlbany College of Pharmacy and Health SciencesUniversity of VermontUniversity of Wisconsin-MadisonBayer AGUniversity of Texas Health San AntonioMolecular Biology ConsortiumUniversity of Lethbridgehttps://doi.org/10.3390/ijms22179128, 2021)
    The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four -helices. ATAD2 functions as a coactivator of the androgen and estrogen receptors as ...
  • Villarreal, Oscar D.; Chen, Liao Y.; Whetten, Robert L.; Demeler, Borries (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas at San AntonioUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.5b09864, 2015)
    Nanometer-sized gold particles (AuNPs) are of peculiar interest because their behaviors in an aqueous solution are sensitive to changes in environmental factors including the size and shape of the solute ions. In order to ...
  • Ballandras-Colas, Allison; Brown, Monica; Cook, Nicola J.; Dewdney, Tamaria G.; Demeler, Borries; Cherepanov, Peter; Lyumkis, Dmitry; Engelman, Alan N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryHarvard Medical SchoolThe Salk Institute for Biological StudiesThe Francis Crick InstituteUniversity of Texas Health Science Center at San AntonioImperial College LondonUniversity of Lethbridgehttps://doi.org/10.1038/nature16955, 2016)
    Retroviral integrase catalyses the integration of viral DNA into host target DNA, which is an essential step in the life cycle of all retroviruses1. Previous structural characterization of integrase–viral DNA complexes, ...
  • Alvarez, Marcos M.; Chen, Jenny; Plascencia-Villa, German; Black, David M.; Griffiths, Wendell P.; Garzon, Ignacio L.; Jose-Yacaman, Miguel; Demeler, Borrie; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasThermoFisher ScientificUniversidad Nacional Autonoma de MexicoUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.6b04525, 2016)
    Experimental and theoretical evidence reveals the resilience and stability of the larger aqueous gold clusters protected with p-mercaptobenzoic acid ligands (pMBA) of composition Aun(pMBA)p or (n, p). The Au144(pMBA)60, ...
  • Rubio-Marrero, Eva N.; Vincelli, Gabriele; Jeffries, Cy M.; Shaikh, Tanvir R.; Pakos, Irene S.; Ranaivoson, Fanomezana M.; von Daake, Sventja; Demeler, Borries; De Jaco, Antonella; Perkins, Guy; Ellisman, Mark H.; Trewhella, Jill; Comoletti, Davide (ASBMB PublicationsArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityUniversity of SydneyMasaryk UniversityUniversity of Texas Health Science Center at San AntonioSapienza University of RomeUniversity of California San DiegoUniversity of UtahUniversity of Lethbridgehttps://doi.org/10.1074/jbc.M115.705681, 2015)
    Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including ...
  • Bhattacharya, Akash; Wang, Zhonghua; White, Tommy; Buffone, Cindy; Nguyen, Laura A.; Shepard, Caitlin N.; Kim, Baek; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1038/srep31353, 2016)
    SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but ...
  • Wong, Sarah J.; Gearhart, Micah D.; Taylor, Alexander B.; Nanyes, David R.; Ha, Daniel J.; Robinson, Angela K.; Artigas, Jason A.; Lee, Oliver J.; Demeler, Borries; Hart, P. John; Bardwell, Vivian J.; Kim, Chongwoo A. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of MinnesotaMidwestern UniversitySouth Texas Veterans Health Care SystemUniversity of Lethbridgehttps://doi.org/10.1016/j.str.2016.07.011, 2016)
    KDM2B recruits H2A-ubiquitinating activity of a non-canonical Polycomb Repression Complex 1 (PRC1.1) to CpG islands, facilitating gene repres sion. We investigated the molecular basis of recruit ment using in vitro ...
  • Karabudak, Engin; Brookes, Emre; Lesnyak, Vladimir; Gaponik, Nikolai; Eychmuller, Alexander; Walter, Johannes; Segets, Doris; Peukert, Wolfgang; Wohlleben, Wendel; Demeler, Borries; Colfen, Helmut (WileyArts and ScienceDepartment of Chemistry and BiochemistryMax Planck Institute of Colloids and InterfacesIzmir Institute of TechnologyUniversity of Texas Health Science Center at San AntonioTU DresdenFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)BASE SEUniversity of Lethbridgehttps://doi.org/10.1002/anie.201603844, 2016)
    We report an unsurpassed solution characterization technique based on analytical ultracentrifugation, which demonstrates exceptional potential for resolving particle sizes in solution with sub-nm resolution. We achieve ...
  • Smirnova, Ekaterina; Kwan, Jamie J.; Siu, Ryan; Gao, Xin; Zoidl, Georg; Demeler, Borries; Saridakis, Vivian; Donaldson, Logan W. (BioMed CentralArts and ScienceDepartment of Chemistry and BiochemistryYork UniversityKing Abdullah University of Science and TechnologyUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1186/s12964-016-0140-3, 2016)
    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASKIN1, CASKIN2 ...
  • Walter, Johannes; Gorbet, Gary E.; Akdas, Tugce; Segets, Doris; Demeler, Borries; Peukert, Wolfgang (Royal Society of ChemistryArts and ScienceDepartment of Chemistry and BiochemistryFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)University of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1039/C6AN02236G, 2017)
    Accurate knowledge of the size, density and composition of nanoparticles (NPs) is of major importance for their applications. In this work the hydrodynamic characterization of polydisperse core–shell NPs by means of ...
  • Lopez, Priscilla; Lara, Humberto H.; Mullins, Sean M.; Black, David M.; Ramsower, Heidi M.; Alvarez, Marcos M.; Williams, Tayler L.; Lopez-Lozano, Xochitl; Weissker, Hans-Christian; Garcia, A. Patricio; Garzon, Ignacio L.; Demeler, Borries; Lopez-Ribot, Jose Luis; Yacaman, Miguel J.; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasUniversity of Texas Health Science Center at San AntonioAix Marseille UniversityUniversidad Nacional Autonoma de MexicoUniversity of Lethbridgehttps://doi.org/10.1021/acsanm.8b00069, 2018)
    Here we report on the identification and applications of an aqueous 29-atom silver cluster stabilized with 12 lipoate ligands, i.e. Ag29(R-α–LA)12 or (29,12), wherein R-α–LA = R-α-lipoic acid, a natural dithiolate. Its ...
  • Wagner, Jonathan M.; Christensen, Devin E.; Bhattacharya, Akash; Dawidziak, Daria M.; Roganowicz, Marcin D.; Wan, Yueping; Pumroy, Ruth A.; Demeler, Borries; Ivanov, Dmitri N.; Ganser-Pornillos, Barbie K.; Sundquist, Wesley I.; Pornillos, Owen (American Society for MicrobiologyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VirginiaUniversity of UtahUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1128/JVI.01563-17, 2018)
    Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, ...
  • Abbott, Jamie A.; Meyer-Schuman, Rebecca; Lupo, Vicenzo; Feeley, Shawna; Mademan, Ines; Oprescu, Stephanie N.; Griffin, Laurie B.; Alberti, M. Antonia; Casasnovas, Carlos; Aharoni, Sharon; Basel-Vanagaite, Lina; Zuchner, Stephan; De Jonghe, Peter; Baets, Jonathan; Shy, Michael E.; Espinos, Carmen; Demeler, Borries; Antonellis, Anthony; Francklyn, Christopher (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VermontUniversity of Michigan Medical SchoolCentro de Investigacion Principe Felipe (CIPF)University of Iowa Hospitals and ClinicsCenter for Molecular NeurologyInstitute Born-BungeHospital Universitario de BellvitgeTel Aviv UniversitySchneider Children's Medical Center of IsraelRabin Medical CenterUniversity of Miami Miller School of MedicineAntwerp University HospitalUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1002/humu.23380, 2018)
    Histidyl-tRNA synthetase (HARS) ligates histidine to cognate tRNA molecules, which is required for protein translation. Mutations in HARS cause the dominant axonal peripheral neuropathy Charcot-Marie-Tooth disease type 2W ...
  • Kim, Haram; Brookes, Emre; Cao, Weiming; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryCornell UniversityUniversity of Texas Health Science Center at San AntonioUniversity of Texas at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1309-z, 2018)
    Sedimentation velocity experiments performed in the analytical ultracentrifuge are modeled using finite-element solutions of the Lamm equation. During modeling, three fundamental parameters are optimized: the sedimentation ...
  • Sterritt, Oliver W.; Lang, Eric J. M.; Kessans, Sarah A.; Ryan, Timothy M.; Demeler, Borries; Jameson, Geoffrey B.; Parker, Emily J. (Portland PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of CanterburyUniversity of AucklandAustralian Synchrotron/ANSTOUniversity of LethbridgeMassey UniversityVictoria University of Wellingtonhttps://doi.org/10.1042/BSR20181605, 2018)
    In Pseudomonas aeruginosa ( Pae ), the shikimate pathway end product, chorismate, serves as the last common precursor for the biosynthesis of both primary aromatic metabolites, including phenylalanine, tyrosine and tryptophan, ...

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