Browsing Demeler, Borries by Title

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  • Stoutjesdyk, Marielle; Henrickson, Amy; Minors, Geoff; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1007/s00249-020-01434-z, 2020)
    Experiments performed in the analytical ultracentrifuge (AUC) measure sedimentation and diffusion coefficients, as well as the partial concentration of colloidal mixtures of molecules in the solution phase. From this ...
  • Evans, Chiara M.; Phillips, Margaret; Malone, Kiera L.; Tonelli, Marco; Cornilescu, Gabriel; Cornilescu, Claudia; Holton, Simon J.; Gorjánácz, Mátyás; Wang, Liping; Carlson, Samuel; Gay, Jamie C.; Nix, Jay C.; Demeler, Borries; Markley, John L.; Glass, Karen C. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryAlbany College of Pharmacy and Health SciencesUniversity of VermontUniversity of Wisconsin-MadisonBayer AGUniversity of Texas Health San AntonioMolecular Biology ConsortiumUniversity of Lethbridgehttps://doi.org/10.3390/ijms22179128, 2021)
    The ATPase Family, AAA domain-containing protein 2 (ATAD2) bromodomain (BRD) has a canonical bromodomain structure consisting of four -helices. ATAD2 functions as a coactivator of the androgen and estrogen receptors as ...
  • Ballandras-Colas, Allison; Brown, Monica; Cook, Nicola J.; Dewdney, Tamaria G.; Demeler, Borries; Cherepanov, Peter; Lyumkis, Dmitry; Engelman, Alan N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryHarvard Medical SchoolThe Salk Institute for Biological StudiesThe Francis Crick InstituteUniversity of Texas Health Science Center at San AntonioImperial College LondonUniversity of Lethbridgehttps://doi.org/10.1038/nature16955, 2016)
    Retroviral integrase catalyses the integration of viral DNA into host target DNA, which is an essential step in the life cycle of all retroviruses1. Previous structural characterization of integrase–viral DNA complexes, ...
  • Bansal, Akanksha; Karanth, N. Megha; Demeler, Borries; Schindelin, Hermann; Sarma, Siddhartha P. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryIndian Institute of Science, BangaloreUniversity of Texas Health Science Center at San AntonioUniversity of WeurzburgUniversity of Lethbridgehttps://doi.org/10.1021/acs.biochem.9b00050, 2019)
    Conformational factors that predicate selectivity for valine or isoleucine binding to IlvN leading to the regulation of aceto hydroxy acid synthase I (AHAS I) of Escherichia coli have been determined for the first time ...
  • Bhattacharya, Akash; Wang, Zhonghua; White, Tommy; Buffone, Cindy; Nguyen, Laura A.; Shepard, Caitlin N.; Kim, Baek; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1038/srep31353, 2016)
    SAMHD1, a dNTP triphosphohydrolase, contributes to interferon signaling and restriction of retroviral replication. SAMHD1-mediated retroviral restriction is thought to result from the depletion of cellular dNTP pools, but ...
  • Kim, Sun Kyung; Barron, Lindsey; Hinck, Cynthia S.; Petrunak, Elyse M.; Cano, Kristin E.; Thangirala, Avinash; Iskra, Brian; Brothers, Molly; Vonberg, Machell; Leal, Belinda; Richter, Blair; Kodali, Ravindra; Taylor, Alexander B.; Du, Shoucheng; Barnes, Christopher O.; Sulea, Traian; Calero, Guillermo; Hart, P. John; Hart, Matthew J.; Demeler, Borries; Hinck, Andrew P. (ASBMB PublicationsArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Pittsburgh School of MedicineUniversity of Texas Health Science Center at San AntonioNational Research Council CanadaUniversity of Lethbridgehttps://doi.org/10.1074/jbc.M116.768754, 2017)
    The transforming growth factor β isoforms, TGF-β1, -β2, and -β3, are small secreted homodimeric signaling proteins with essential roles in regulating the adaptive immune system and maintaining the extracellular matrix. ...
  • Wang, Zhonghua; Bhattacharya, Akash; White, Tommy; Buffone, Cindy; McCabe, Aine; Nguyen, Laura A.; Shepard, Caitlin N.; Pardo, Sammy; Kim, Baek; Weintraub, Susan T.; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science CenterAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1016/j.celrep.2018.06.090, 2018)
    SAMHD1 is a dNTP triphosphohydrolase (dNTPase)that impairs retroviral replication in a subset of non-cycling immune cells. Here we show that SAMHD1is a redox-sensitive enzyme and identify threeredox-active cysteines within ...
  • Wagner, Jonathan M.; Christensen, Devin E.; Bhattacharya, Akash; Dawidziak, Daria M.; Roganowicz, Marcin D.; Wan, Yueping; Pumroy, Ruth A.; Demeler, Borries; Ivanov, Dmitri N.; Ganser-Pornillos, Barbie K.; Sundquist, Wesley I.; Pornillos, Owen (American Society for MicrobiologyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VirginiaUniversity of UtahUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1128/JVI.01563-17, 2018)
    Restriction factors are intrinsic cellular defense proteins that have evolved to block microbial infections. Retroviruses such as HIV-1 are restricted by TRIM5 proteins, which recognize the viral capsid shell that surrounds, ...
  • Alvarez, Marcos M.; Chen, Jenny; Plascencia-Villa, German; Black, David M.; Griffiths, Wendell P.; Garzon, Ignacio L.; Jose-Yacaman, Miguel; Demeler, Borrie; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasThermoFisher ScientificUniversidad Nacional Autonoma de MexicoUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.jpcb.6b04525, 2016)
    Experimental and theoretical evidence reveals the resilience and stability of the larger aqueous gold clusters protected with p-mercaptobenzoic acid ligands (pMBA) of composition Aun(pMBA)p or (n, p). The Au144(pMBA)60, ...
  • Nelson, Corey R.; Mrozowich, Tyler; Park, Sean M.; D'souza, Simmone; Henrickson, Amy; Vigar, Justin R. J.; Wieden, Hans-Joachim; Owens, Raymond J.; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryRutherford Appleton LaboratoriesUniversity of MontanaUniversity of Albertahttps://doi.org/10.3390/ijms22010054, 2020)
    Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase ...
  • Wong, Sarah J.; Gearhart, Micah D.; Taylor, Alexander B.; Nanyes, David R.; Ha, Daniel J.; Robinson, Angela K.; Artigas, Jason A.; Lee, Oliver J.; Demeler, Borries; Hart, P. John; Bardwell, Vivian J.; Kim, Chongwoo A. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of MinnesotaMidwestern UniversitySouth Texas Veterans Health Care SystemUniversity of Lethbridgehttps://doi.org/10.1016/j.str.2016.07.011, 2016)
    KDM2B recruits H2A-ubiquitinating activity of a non-canonical Polycomb Repression Complex 1 (PRC1.1) to CpG islands, facilitating gene repres sion. We investigated the molecular basis of recruit ment using in vitro ...
  • Stoutjesdyk, Marielle; Brookes, Emre; Henrickson, Amy; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1007/s00249-020-01482-5, 2020)
    A method is described to accurately measure the compressibility of liquids using an analytical ultracentrifuge. The method makes use of very large pressure gradients, which can be generated in the analytical ultracentrifuge ...
  • Demeler, Borries (Portland PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1042/BIO04102014, 2019)
    In 1926, the Swedish scientist Theodor Svedberg was awarded the Nobel Prize in Chemistry for his work on a disperse system, and for studying the colloidal properties of proteins. This work was, to a ...
  • Horne, Christoper R.; Venugopal, Hariprasad; Panjikar, Santosh; Wood, David M.; Henrickson, Amy; Brookes, Emre; North, Rachel A.; Murphy, James M.; Friemann, Rosmarie; Griffin, Michael D. W.; Ramm, Georg; Demeler, Borries; Dobson, Renwick C. J. (Nature Publishing GroupArts and ScienceDepartment of Chemistry and BiochemistryUniversity of CenterburyMonash UniversityUniversity of LethbridgeUniversity of MontanaUniversity of MelbourneSahlgrenska University HospitalUniversity of Gothenburghttps://doi.org/10.1038/s41467-021-22253-6, 2021)
    Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a nutrient source for pathogenic and commensal bacteria. The ...
  • Soares, Barbara S.; Rocha, Surza Lucia G.; Bastos, Viviane A.; Lima, Diogo B.; Carvalho, Paulo C.; Gozzo, Fabio C.; Demeler, Borries; Williams, Tayler L.; Arnold, Janelle; Henrickson, Amy; Jorgensen, Thomas J. D.; Souza, Tatiana A. C. B.; Perales, Jonas; Valente, Richard H.; Lomonte, Bruno; Gomes-Neto, Francisco; Neves-Ferreira, Ana Gisele C. (Frontiers Research FoundationArts and ScienceDepartment of Chemistry and BiochemistryOswaldo Cruz InstituteLeibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)Carlos Chagas InstituteUniversity of CampinasUniversity of Texas Health Science Center at San AntonioUniversity of LethbridgeUniversity of MontanaPrinceton UniversityUniversity of Southern DenmarkUniversity of Costa Ricahttps://doi.org/10.3389/fmolb.2021.787368, 2022)
    DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account ...
  • Savelyev, Alexey; Gorbet, Gary E.; Henrickson, Amy; Demeler, Borries (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MontanaAUC SolutionsUniversity of Lethbridgehttps://doi.org/10.1371/journal.pcbi.1007942, 2020)
    Recent advances in instrumentation have moved analytical ultracentrifugation (AUC) closer to a possible validation in a Good Manufacturing Practices (GMP) environment. In order for AUC to be validated for a GMP environment, ...
  • Williams, Taylor L.; Gorbet, Gary E.; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1297-z, 2018)
    A framework for the global analysis of multi-speed analytical ultracentrifugation sedimentation velocity experiments is presented. We discuss extensions to the adaptive space–time finite element fitting methods implemented ...
  • Johnson, Courtney N.; Gorbet, Gary E.; Ramsower, Heidi; Urquidi, Julio; Brancaleon, Lorenzo; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Texas at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1301-7, 2018)
    The new Beckman Coulter Optima AUC instrument, which features multi-wavelength detection that couples the hydro- dynamic separation of colloidal mixtures to spectral deconvolution of interacting and non-interacting solutes ...
  • Gorbet, Gary E.; Mohapatra, Subhashree; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1297-z, 2018)
    A framework for the global analysis of multi-speed analytical ultracentrifugation sedimentation velocity experiments is presented. We discuss extensions to the adaptive space–time finite element fitting methods implemented ...
  • Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of MontanaUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/v12020190, 2020)
    Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence ...