Browsing Demeler, Borries by Title

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  • Stoutjesdyk, Marielle; Brookes, Emre; Henrickson, Amy; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1007/s00249-020-01482-5, 2020)
    A method is described to accurately measure the compressibility of liquids using an analytical ultracentrifuge. The method makes use of very large pressure gradients, which can be generated in the analytical ultracentrifuge ...
  • Demeler, Borries (Portland PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1042/BIO04102014, 2019)
    In 1926, the Swedish scientist Theodor Svedberg was awarded the Nobel Prize in Chemistry for his work on a disperse system, and for studying the colloidal properties of proteins. This work was, to a ...
  • Horne, Christoper R.; Venugopal, Hariprasad; Panjikar, Santosh; Wood, David M.; Henrickson, Amy; Brookes, Emre; North, Rachel A.; Murphy, James M.; Friemann, Rosmarie; Griffin, Michael D. W.; Ramm, Georg; Demeler, Borries; Dobson, Renwick C. J. (Nature Publishing GroupArts and ScienceDepartment of Chemistry and BiochemistryUniversity of CenterburyMonash UniversityUniversity of LethbridgeUniversity of MontanaUniversity of MelbourneSahlgrenska University HospitalUniversity of Gothenburghttps://doi.org/10.1038/s41467-021-22253-6, 2021)
    Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a nutrient source for pathogenic and commensal bacteria. The ...
  • Soares, Barbara S.; Rocha, Surza Lucia G.; Bastos, Viviane A.; Lima, Diogo B.; Carvalho, Paulo C.; Gozzo, Fabio C.; Demeler, Borries; Williams, Tayler L.; Arnold, Janelle; Henrickson, Amy; Jorgensen, Thomas J. D.; Souza, Tatiana A. C. B.; Perales, Jonas; Valente, Richard H.; Lomonte, Bruno; Gomes-Neto, Francisco; Neves-Ferreira, Ana Gisele C. (Frontiers Research FoundationArts and ScienceDepartment of Chemistry and BiochemistryOswaldo Cruz InstituteLeibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)Carlos Chagas InstituteUniversity of CampinasUniversity of Texas Health Science Center at San AntonioUniversity of LethbridgeUniversity of MontanaPrinceton UniversityUniversity of Southern DenmarkUniversity of Costa Ricahttps://doi.org/10.3389/fmolb.2021.787368, 2022)
    DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account ...
  • Savelyev, Alexey; Gorbet, Gary E.; Henrickson, Amy; Demeler, Borries (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MontanaAUC SolutionsUniversity of Lethbridgehttps://doi.org/10.1371/journal.pcbi.1007942, 2020)
    Recent advances in instrumentation have moved analytical ultracentrifugation (AUC) closer to a possible validation in a Good Manufacturing Practices (GMP) environment. In order for AUC to be validated for a GMP environment, ...
  • Williams, Taylor L.; Gorbet, Gary E.; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1297-z, 2018)
    A framework for the global analysis of multi-speed analytical ultracentrifugation sedimentation velocity experiments is presented. We discuss extensions to the adaptive space–time finite element fitting methods implemented ...
  • Johnson, Courtney N.; Gorbet, Gary E.; Ramsower, Heidi; Urquidi, Julio; Brancaleon, Lorenzo; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Texas at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1301-7, 2018)
    The new Beckman Coulter Optima AUC instrument, which features multi-wavelength detection that couples the hydro- dynamic separation of colloidal mixtures to spectral deconvolution of interacting and non-interacting solutes ...
  • Gorbet, Gary E.; Mohapatra, Subhashree; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1297-z, 2018)
    A framework for the global analysis of multi-speed analytical ultracentrifugation sedimentation velocity experiments is presented. We discuss extensions to the adaptive space–time finite element fitting methods implemented ...
  • Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of MontanaUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/v12020190, 2020)
    Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence ...
  • Mullen, Patrick; Abbott, Jamie A.; Wellman, Theresa; Aktar, Mahafuza; Fjeld, Christian; Demeler, Borries; Ebert, Alicia M.; Francklyn, Christopher S. (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VermontUniversity of Lethbridgehttps://doi.org/10.1111/febs.15449, 2021)
    Charcot-Marie-Tooth disease (CMT) encompasses a set of genetically and clinically heterogeneous neuropathies characterized by length dependent dysfunction of the peripheral nervous system. Mutations in over 80 diverse genes ...
  • Smirnova, Ekaterina; Kwan, Jamie J.; Siu, Ryan; Gao, Xin; Zoidl, Georg; Demeler, Borries; Saridakis, Vivian; Donaldson, Logan W. (BioMed CentralArts and ScienceDepartment of Chemistry and BiochemistryYork UniversityKing Abdullah University of Science and TechnologyUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1186/s12964-016-0140-3, 2016)
    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASKIN1, CASKIN2 ...
  • Hu, Jie; Soraiz, Eduardo Hernandez; Johnson, Courtney N.; Demeler, Borries; Brancaleon, Lorenzo (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas at San AntonioUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1016/j.ijbiomac.2019.05.060, 2019)
    The evidence that Human Serum Albumin (HSA) binds metal ions and organometallic compounds has generated interest in its physiological role as a metalloprotein and as a vehicle for synthetic biology applications (e.g., ...
  • Yu, Corey H.; Bhattacharya, Akash; Persaud, Mirjana; Taylor, Alexander B.; Wang, Zhonghua; Bulnes-Ramos, Angel; Xu, Joella; Selyutina, Anastasia; Martinez-Lopez, Alicia; Cano, Kristin; Demeler, Borries; Kim, Baek; Hardies, Stephen C.; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Nature Publishing GroupArts and ScienceDepartment of Chemistry and BiochemistryUT Health San AntonioAlbert Einstein College of MedicineEmory School of MedicineUniversity of LethbridgeUniversity of Montanahttps://doi.org/10.1038/s41467-021-21023-8, 2021)
    SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates (dNTPs)—implicates enzymatic dNTP depletion ...
  • Koebke, Karl J.; Kühl, Toni; Lojou, Elisabeth; Demeler, Borries; Schoepp-Cothenet, Barbara; Iranzo, Olga; Pecoraro, Vincent L.; Ivancich, Anabella (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MichiganAix-Marseille UniversityUniversity of Lethbridgehttps://doi.org/10.1002/anie.202012673, 2021)
    De Novo metalloprotein design assesses the relationship between metal active site architecture and catalytic reactivity. Herein, we use an α-helical scaffold to control the iron coordination geometry when a heme cofactor ...
  • Tian, Shaoxiong; Yu, Ge; He, Huan; Zhao, Yu; Liu, Peilu; Marshall, Alan G.; Demeler, Borries; Stagg, Scott M.; Li, Hong (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryFlorida State UniversityUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttp://dx.doi.org/10.1016/j.str.2017.08.002, 2017)
    The Saccharomyces cerevisiae (Sc) R2TP complex affords an Hsp90-mediated and nucleotide-driven chaperone activity to proteins of small ribonucleoprotein particles (snoRNPs). The current lack of structural information on ...
  • Ranaivoson, Fanomezana M.; Turk, Liam S.; Ozgul, Sinem; Kakehi, Sumie; von Daake, Sventja; Lopez, Nicole; Trobiani, Laura; De Jaco, Antonella; Denissova, Natalia; Demeler, Borries; Özkan, Engin; Montelione, Gaetano T.; Comoletti, Davide (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryChild Health Institute of New JerseySapienza University of RomeRutgers UniversityUniversity of LethbridgeUniversity of Chicagohttps://doi.org/10.1016/j.str.2019.03.004, 2019)
    In the developing brain, cell-surface proteins play crucial roles, but their protein-protein interaction network remains largely unknown. A proteomic screen identified 200 interactions, 89 of which were not previously ...
  • Tersteeg, Scott; Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (Canadian Science PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of AlbertaUniversity of Calgaryhttps://doi.org/10.1139/bcb-2022-0118, 2022)
    Inorganic pyrophosphatase (iPPase) is an enzyme that cleaves pyrophosphate into two phosphate molecules. This enzyme is an essential component of in vitro transcription (IVT) reactions for RNA preparation as it prevents ...
  • Salveson, Patrick J.; Haerianardakani, Sepehr; Thuy-Boun, Alexander; Yoo, Stan; Kreutzer, Adam G.; Demeler, Borries; Nowick, James S. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of California IrvineUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/jacs.8b06568, 2018)
    Soluble oligomers of the β-amyloid peptide, Aβ, are associated with the progression of Alzheimer’s disease. Although many small molecules bind to these assemblies, the details of how these molecules interact with Aβ oligomers ...
  • Karabudak, Engin; Brookes, Emre; Lesnyak, Vladimir; Gaponik, Nikolai; Eychmuller, Alexander; Walter, Johannes; Segets, Doris; Peukert, Wolfgang; Wohlleben, Wendel; Demeler, Borries; Colfen, Helmut (WileyArts and ScienceDepartment of Chemistry and BiochemistryMax Planck Institute of Colloids and InterfacesIzmir Institute of TechnologyUniversity of Texas Health Science Center at San AntonioTU DresdenFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)BASE SEUniversity of Lethbridgehttps://doi.org/10.1002/anie.201603844, 2016)
    We report an unsurpassed solution characterization technique based on analytical ultracentrifugation, which demonstrates exceptional potential for resolving particle sizes in solution with sub-nm resolution. We achieve ...
  • Zhang, Jin; Pearson, Joseph Z.; Gorbet, Gary E.; Cölfen, Helmut; Germann, Markus W.; Brinton, Margo A.; Demeler, Borries (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryGeorgia State UniversityUniversity of KonstanzUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.analchem.6b03926, 2017)
    Interactions between nucleic acids and proteins are critical for many cellular processes, and their study is of utmost importance to many areas of biochemistry, cellular biology, and virology. Here, we introduce a new ...