Browsing Demeler, Borries by Title

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  • Koebke, Karl J.; Kühl, Toni; Lojou, Elisabeth; Demeler, Borries; Schoepp-Cothenet, Barbara; Iranzo, Olga; Pecoraro, Vincent L.; Ivancich, Anabella (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MichiganAix-Marseille UniversityUniversity of Lethbridgehttps://doi.org/10.1002/anie.202012673, 2021)
    De Novo metalloprotein design assesses the relationship between metal active site architecture and catalytic reactivity. Herein, we use an α-helical scaffold to control the iron coordination geometry when a heme cofactor ...
  • Tian, Shaoxiong; Yu, Ge; He, Huan; Zhao, Yu; Liu, Peilu; Marshall, Alan G.; Demeler, Borries; Stagg, Scott M.; Li, Hong (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryFlorida State UniversityUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttp://dx.doi.org/10.1016/j.str.2017.08.002, 2017)
    The Saccharomyces cerevisiae (Sc) R2TP complex affords an Hsp90-mediated and nucleotide-driven chaperone activity to proteins of small ribonucleoprotein particles (snoRNPs). The current lack of structural information on ...
  • Ranaivoson, Fanomezana M.; Turk, Liam S.; Ozgul, Sinem; Kakehi, Sumie; von Daake, Sventja; Lopez, Nicole; Trobiani, Laura; De Jaco, Antonella; Denissova, Natalia; Demeler, Borries; Özkan, Engin; Montelione, Gaetano T.; Comoletti, Davide (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryChild Health Institute of New JerseySapienza University of RomeRutgers UniversityUniversity of LethbridgeUniversity of Chicagohttps://doi.org/10.1016/j.str.2019.03.004, 2019)
    In the developing brain, cell-surface proteins play crucial roles, but their protein-protein interaction network remains largely unknown. A proteomic screen identified 200 interactions, 89 of which were not previously ...
  • Tersteeg, Scott; Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (Canadian Science PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of AlbertaUniversity of Calgaryhttps://doi.org/10.1139/bcb-2022-0118, 2022)
    Inorganic pyrophosphatase (iPPase) is an enzyme that cleaves pyrophosphate into two phosphate molecules. This enzyme is an essential component of in vitro transcription (IVT) reactions for RNA preparation as it prevents ...
  • Salveson, Patrick J.; Haerianardakani, Sepehr; Thuy-Boun, Alexander; Yoo, Stan; Kreutzer, Adam G.; Demeler, Borries; Nowick, James S. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of California IrvineUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/jacs.8b06568, 2018)
    Soluble oligomers of the β-amyloid peptide, Aβ, are associated with the progression of Alzheimer’s disease. Although many small molecules bind to these assemblies, the details of how these molecules interact with Aβ oligomers ...
  • Karabudak, Engin; Brookes, Emre; Lesnyak, Vladimir; Gaponik, Nikolai; Eychmuller, Alexander; Walter, Johannes; Segets, Doris; Peukert, Wolfgang; Wohlleben, Wendel; Demeler, Borries; Colfen, Helmut (WileyArts and ScienceDepartment of Chemistry and BiochemistryMax Planck Institute of Colloids and InterfacesIzmir Institute of TechnologyUniversity of Texas Health Science Center at San AntonioTU DresdenFriedrich-Alexander-Universitat Erlangen-Nurnberg (FAU)BASE SEUniversity of Lethbridgehttps://doi.org/10.1002/anie.201603844, 2016)
    We report an unsurpassed solution characterization technique based on analytical ultracentrifugation, which demonstrates exceptional potential for resolving particle sizes in solution with sub-nm resolution. We achieve ...
  • Zhang, Jin; Pearson, Joseph Z.; Gorbet, Gary E.; Cölfen, Helmut; Germann, Markus W.; Brinton, Margo A.; Demeler, Borries (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryGeorgia State UniversityUniversity of KonstanzUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1021/acs.analchem.6b03926, 2017)
    Interactions between nucleic acids and proteins are critical for many cellular processes, and their study is of utmost importance to many areas of biochemistry, cellular biology, and virology. Here, we introduce a new ...
  • Sterritt, Oliver W.; Lang, Eric J. M.; Kessans, Sarah A.; Ryan, Timothy M.; Demeler, Borries; Jameson, Geoffrey B.; Parker, Emily J. (Portland PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of CanterburyUniversity of AucklandAustralian Synchrotron/ANSTOUniversity of LethbridgeMassey UniversityVictoria University of Wellingtonhttps://doi.org/10.1042/BSR20181605, 2018)
    In Pseudomonas aeruginosa ( Pae ), the shikimate pathway end product, chorismate, serves as the last common precursor for the biosynthesis of both primary aromatic metabolites, including phenylalanine, tyrosine and tryptophan, ...
  • Rubio-Marrero, Eva N.; Vincelli, Gabriele; Jeffries, Cy M.; Shaikh, Tanvir R.; Pakos, Irene S.; Ranaivoson, Fanomezana M.; von Daake, Sventja; Demeler, Borries; De Jaco, Antonella; Perkins, Guy; Ellisman, Mark H.; Trewhella, Jill; Comoletti, Davide (ASBMB PublicationsArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityUniversity of SydneyMasaryk UniversityUniversity of Texas Health Science Center at San AntonioSapienza University of RomeUniversity of California San DiegoUniversity of UtahUniversity of Lethbridgehttps://doi.org/10.1074/jbc.M115.705681, 2015)
    Contactin-associated protein-like 2 (CNTNAP2) encodes for CASPR2, a multidomain single transmembrane protein belonging to the neurexin superfamily that has been implicated in a broad range of human phenotypes including ...
  • Fan, Yanlin; Guo, Yusong R.; Yuan, Wang; Zhou, Ying; Holt, Matthew V.; Wang, Tao; Demeler, Borries; Young, Nicolas L.; Zhong, Weiwei; Tao, Yizhi J. (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryRice UniversityBaylor College of MedicineUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1371/journal.ppat.1006231, 2017)
    Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until six years ago. The Orsay virus and its related nematode viruses have a ...
  • Adusei-Danso, Felix; Khaja, Faisal Tarique; DeSantis, Micaela; Jeffrey, Philip D.; Dubnau, Eugenie; Demeler, Borries; Neiditch, Matthew B.; Dubnau, David (American Society for MicrobiologyArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityCenter of New Jersey Medical SchoolPrinceton UniversityUniversity of Lethbridgehttps://doi.org/10.1128/mBio.01841-19, 2019)
    In Bacillus subtilis, the RicA (YmcA), RicF (YlbF), and RicT (YaaT) proteins accelerate the phosphorylation of the transcription factor Spo0A, contributing to ge netic competence, sporulation, and biofilm formation, and ...
  • Abbott, Jamie A.; Meyer-Schuman, Rebecca; Lupo, Vicenzo; Feeley, Shawna; Mademan, Ines; Oprescu, Stephanie N.; Griffin, Laurie B.; Alberti, M. Antonia; Casasnovas, Carlos; Aharoni, Sharon; Basel-Vanagaite, Lina; Zuchner, Stephan; De Jonghe, Peter; Baets, Jonathan; Shy, Michael E.; Espinos, Carmen; Demeler, Borries; Antonellis, Anthony; Francklyn, Christopher (WileyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of VermontUniversity of Michigan Medical SchoolCentro de Investigacion Principe Felipe (CIPF)University of Iowa Hospitals and ClinicsCenter for Molecular NeurologyInstitute Born-BungeHospital Universitario de BellvitgeTel Aviv UniversitySchneider Children's Medical Center of IsraelRabin Medical CenterUniversity of Miami Miller School of MedicineAntwerp University HospitalUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1002/humu.23380, 2018)
    Histidyl-tRNA synthetase (HARS) ligates histidine to cognate tRNA molecules, which is required for protein translation. Mutations in HARS cause the dominant axonal peripheral neuropathy Charcot-Marie-Tooth disease type 2W ...
  • Lopez, Priscilla; Lara, Humberto H.; Mullins, Sean M.; Black, David M.; Ramsower, Heidi M.; Alvarez, Marcos M.; Williams, Tayler L.; Lopez-Lozano, Xochitl; Weissker, Hans-Christian; Garcia, A. Patricio; Garzon, Ignacio L.; Demeler, Borries; Lopez-Ribot, Jose Luis; Yacaman, Miguel J.; Whetten, Robert L. (American Chemical SocietyArts and ScienceDepartment of Chemistry and BiochemistryUniversity of TexasUniversity of Texas Health Science Center at San AntonioAix Marseille UniversityUniversidad Nacional Autonoma de MexicoUniversity of Lethbridgehttps://doi.org/10.1021/acsanm.8b00069, 2018)
    Here we report on the identification and applications of an aqueous 29-atom silver cluster stabilized with 12 lipoate ligands, i.e. Ag29(R-α–LA)12 or (29,12), wherein R-α–LA = R-α-lipoic acid, a natural dithiolate. Its ...
  • Kim, Haram; Brookes, Emre; Cao, Weiming; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryCornell UniversityUniversity of Texas Health Science Center at San AntonioUniversity of Texas at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1309-z, 2018)
    Sedimentation velocity experiments performed in the analytical ultracentrifuge are modeled using finite-element solutions of the Lamm equation. During modeling, three fundamental parameters are optimized: the sedimentation ...