dc.contributor.author |
Guimaraes, Ivelise D. L. |
|
dc.contributor.author |
Marszaukowski, Flávia |
|
dc.contributor.author |
Rutka, Priscila B. |
|
dc.contributor.author |
Borge, Luis F. |
|
dc.contributor.author |
Ribeiro, Renan A. P. |
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dc.contributor.author |
Ricardo de Lazaro, Sergio |
|
dc.contributor.author |
Castellen, Patrícia |
|
dc.contributor.author |
Sagoe-Wagner, Araba |
|
dc.contributor.author |
Golsteyn, Roy M. |
|
dc.contributor.author |
Boeré, René T. |
|
dc.contributor.author |
Wohnrath, Karen |
|
dc.date.accessioned |
2022-08-26T19:15:54Z |
|
dc.date.available |
2022-08-26T19:15:54Z |
|
dc.date.issued |
2022 |
|
dc.identifier.citation |
Guimaraes, I. D. L., Marszaukowski, F., Rutka, P. B., Borge, L. F., Ribeiro, R. A. P., Ricardo de Lazaro, S., Castellen, P., Sagoe-Wagner, A., Golsteyn, R. M., Boeré, R. T., & Wohnrath, K. (2022).Synthesis, characterization and anticancer activities of cationic η6-p-cymene ruthenium(II) complexes containing phosphine and nitrogenous ligands. Polyhedron, 15. Retrieved from https://hdl.handle.net/10133/6325 |
en_US |
dc.identifier.uri |
https://hdl.handle.net/10133/6325 |
|
dc.description |
Accepted author manuscript. Embargo in effect until June 23, 2024 |
en_US |
dc.description.abstract |
Ruthenium-based anticancer agents have created a center of attention in the field of inorganic medicinal chemistry. The first fully characterized cationic ruthenium(II)-arene complexes [Ru(η6-p-cymene) (PAr3)LNCl]+ with highly lipophilic PAr3 ligands where Ar = 3,5-((CH3)3C)2C6H3– (L1), 3,5-(CH3)2C6H3– (L2), 4-CH3O-3,5-(CH3)2C6H2– (L3) and 4-CH3O-C6H4– (L4) with N = 3-methylpyridine (1–4, respectively), or L4 and 4-methylpyridine (5), or L4 and CH3CN (6) were obtained (yields 67–91%) as solids stable to light and air. Electrical conductance indicates that all the complexes are 1:1 electrolytes in solution. Their composition and purity have been unambiguously established by single-crystal X-ray diffraction, NMR spectroscopy and elemental analysis. The coordination geometries are uniform for all six complexes and each structure consist of a unipositive complex cation bearing the phosphine ligands L1-L4 and LN = 3-methylpyridine, 4-methylpyridine or CH3CN attached to the organometallic fragment. The equivalent unit cell volumes per formula unit decrease with 1 > 3 > 2 > 4 > 5 > 6, accurately reflecting the decreasing sizes of the phosphines L1-L4, and a greater occupied volume for 3-methyl- vs. 4-methylpyridine, and the smallest volume contribution from CH3CN. Electrochemical studies showed mixed electrochemical mechanisms (EC/ECE) from partial substitution of p-cymene by CH3CN ligands from the solvent. A large electrochemical stability window (>2.2 V) for Ru(II) was observed extending beyond the physiological E° range. The complexes were cytotoxic against human cancer cell lines in vitro, and some complexes altered cell morphology. |
en_US |
dc.language.iso |
en_US |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.subject |
Cationic ruthenium-arene |
en_US |
dc.subject |
Triarylphosphine |
en_US |
dc.subject |
Pyridine derivative |
en_US |
dc.subject |
Cyclic voltammetry |
en_US |
dc.subject |
Cytotoxicity assays |
en_US |
dc.subject |
DFT calculations |
en_US |
dc.subject.lcsh |
Pyridine--Derivatives |
|
dc.title |
Synthesis, characterization and anticancer activities of cationic η6-p-cymene ruthenium(II) complexes containing phosphine and nitrogenous ligands |
en_US |
dc.type |
Article |
en_US |
dc.publisher.faculty |
Arts and Science |
en_US |
dc.publisher.department |
Department of Biological Sciences |
en_US |
dc.publisher.department |
Department of Chemistry and Biochemistry |
en_US |
dc.publisher.institution |
Universidade Estadual de Ponta Grossa |
en_US |
dc.publisher.institution |
Universidade do Estado de Minas Gerais |
en_US |
dc.publisher.institution |
Instituto Federal Catarinense, Rua das Rosas |
en_US |
dc.publisher.institution |
University of Lethbridge |
en_US |
dc.publisher.url |
https://doi.org/10.1016/j.poly.2022.115980 |
en_US |