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dc.contributor.author Guimaraes, Ivelise D. L.
dc.contributor.author Marszaukowski, Flávia
dc.contributor.author Rutka, Priscila B.
dc.contributor.author Borge, Luis F.
dc.contributor.author Ribeiro, Renan A. P.
dc.contributor.author Ricardo de Lazaro, Sergio
dc.contributor.author Castellen, Patrícia
dc.contributor.author Sagoe-Wagner, Araba
dc.contributor.author Golsteyn, Roy M.
dc.contributor.author Boeré, René T.
dc.contributor.author Wohnrath, Karen
dc.date.accessioned 2022-08-26T19:15:54Z
dc.date.available 2022-08-26T19:15:54Z
dc.date.issued 2022
dc.identifier.citation Guimaraes, I. D. L., Marszaukowski, F., Rutka, P. B., Borge, L. F., Ribeiro, R. A. P., Ricardo de Lazaro, S., Castellen, P., Sagoe-Wagner, A., Golsteyn, R. M., Boeré, R. T., & Wohnrath, K. (2022).Synthesis, characterization and anticancer activities of cationic η6-p-cymene ruthenium(II) complexes containing phosphine and nitrogenous ligands. Polyhedron, 15. Retrieved from https://hdl.handle.net/10133/6325 en_US
dc.identifier.uri https://hdl.handle.net/10133/6325
dc.description Accepted author manuscript. Embargo in effect until June 23, 2024 en_US
dc.description.abstract Ruthenium-based anticancer agents have created a center of attention in the field of inorganic medicinal chemistry. The first fully characterized cationic ruthenium(II)-arene complexes [Ru(η6-p-cymene) (PAr3)LNCl]+ with highly lipophilic PAr3 ligands where Ar = 3,5-((CH3)3C)2C6H3– (L1), 3,5-(CH3)2C6H3– (L2), 4-CH3O-3,5-(CH3)2C6H2– (L3) and 4-CH3O-C6H4– (L4) with N = 3-methylpyridine (1–4, respectively), or L4 and 4-methylpyridine (5), or L4 and CH3CN (6) were obtained (yields 67–91%) as solids stable to light and air. Electrical conductance indicates that all the complexes are 1:1 electrolytes in solution. Their composition and purity have been unambiguously established by single-crystal X-ray diffraction, NMR spectroscopy and elemental analysis. The coordination geometries are uniform for all six complexes and each structure consist of a unipositive complex cation bearing the phosphine ligands L1-L4 and LN = 3-methylpyridine, 4-methylpyridine or CH3CN attached to the organometallic fragment. The equivalent unit cell volumes per formula unit decrease with 1 > 3 > 2 > 4 > 5 > 6, accurately reflecting the decreasing sizes of the phosphines L1-L4, and a greater occupied volume for 3-methyl- vs. 4-methylpyridine, and the smallest volume contribution from CH3CN. Electrochemical studies showed mixed electrochemical mechanisms (EC/ECE) from partial substitution of p-cymene by CH3CN ligands from the solvent. A large electrochemical stability window (>2.2 V) for Ru(II) was observed extending beyond the physiological E° range. The complexes were cytotoxic against human cancer cell lines in vitro, and some complexes altered cell morphology. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Cationic ruthenium-arene en_US
dc.subject Triarylphosphine en_US
dc.subject Pyridine derivative en_US
dc.subject Cyclic voltammetry en_US
dc.subject Cytotoxicity assays en_US
dc.subject DFT calculations en_US
dc.subject.lcsh Pyridine--Derivatives
dc.title Synthesis, characterization and anticancer activities of cationic η6-p-cymene ruthenium(II) complexes containing phosphine and nitrogenous ligands en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.publisher.department Department of Chemistry and Biochemistry en_US
dc.publisher.institution Universidade Estadual de Ponta Grossa en_US
dc.publisher.institution Universidade do Estado de Minas Gerais en_US
dc.publisher.institution Instituto Federal Catarinense, Rua das Rosas en_US
dc.publisher.institution University of Lethbridge en_US
dc.publisher.url https://doi.org/10.1016/j.poly.2022.115980 en_US


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